ICH Treatments - Arzna Labs Inc

You never fail until you stop trying.

Albert Einstein (1879–1955)

Hemorrhagic stroke represents about 13% of all strokes and is caused by intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH) [1,2]. ICH accounts for about 10% of all strokes in Western populations, and 20–30% in Asian populations [1,3,4,8].

Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke with high disability and high mortality rates [4,5,8]. To date no intervention has demonstrated clear efficacy in improving outcomes [3,6,10].

Current primary intracerebral hemorrhage (ICH) treatments focus on limiting hematoma volume by lowering blood pressure, reversing anticoagulation, or hematoma evacuation [7,9]. Nevertheless, outcome after ICH has not improved over the last few decades [8]. Few evidence-based treatments have been available, leading to an attitude of clinical nihilism including early palliation [8].

References

Khattar NK, Williams BJ, Ding D, et al. Chapter 22 Neuroprotective Strategies in Hemorrhagic Stroke. In: Lapchak PA, YANG GY, editors. Translational Research in Stroke. Singapore: Springer Singapore, 2017. P492.
Xu R, Gjpro A, Schneider UC, et al. Chapter 13 Microglia Function in Stroke. In: Lapchak PA, YANG GY, editors. Translational Research in Stroke. Singapore: Springer Singapore, 2017. P281.
Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke 2022; 53(7): e282-e361.
Xiao L, Zheng H, Li J, Wang Q, et al. Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets. Mol Neurobiol. 2020; 57(12): 5130-5149.
Li J, Xiao L, He D, et al. Mechanism of White Matter Injury and Promising Therapeutic Strategies of MSCs After Intracerebral Hemorrhage. Front Aging Neurosci. 2021; 13: 632054.
Ganesh Kumar N, Zuckerman SL, Khan IS, et al. Treatment of intracerebral hemorrhage: a selective review and future directions. J Neurosurg Sci. 2017; 61(5): 523-535.
Ramadhan MIA, Sitanaya SN, Hakim AHW, et al. The Role of Iron-Chelating Therapy in Improving Neurological Outcome in Patients with Intracerebral Hemorrhage: Evidence-Based Case Report. Medicina (Kaunas). 2023; 59(3): 453.
Hostettler IC, Seiffge DJ, Werring DJ. Intracerebral hemorrhage: an update on diagnosis and treatment. Expert Rev Neurother. 2019; 19(7): 679-694.
Reyes R, Viswanathan M, Aiyagari V. An update on neurocritical care for intracerebral hemorrhage. Expert Rev Neurother. 2019; 19(6): 557-578.
Sembill JA, Kuramatsu JB. Akutbehandlung der intrazerebralen Blutung [Acute treatment of intracerebral hemorrhage]. Med Klin Intensivmed Notfmed. 2019; 114(7): 613-619.

Hemorrhagic stroke represents about 13% of all strokes and is caused by intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH) [1,2]. ICH accounts for about 10% of all strokes in Western populations, and 20–30% in Asian populations [1,3,4,8].

Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke with high disability and high mortality rates [4,5,8]. To date no intervention has demonstrated clear efficacy in improving outcomes [3,6,10].

References

Khattar NK, Williams BJ, Ding D, et al. Chapter 22 Neuroprotective Strategies in Hemorrhagic Stroke. In: Lapchak PA, YANG GY, editors. Translational Research in Stroke. Singapore: Springer Singapore, 2017. P492.

Xu R, Gjpro A, Schneider UC, et al. Chapter 13 Microglia Function in Stroke. In: Lapchak PA, YANG GY, editors. Translational Research in Stroke. Singapore: Springer Singapore, 2017. P281.

Greenberg SM, Ziai WC, Cordonnier C, et al. 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association. Stroke 2022; 53(7): e282-e361.

Xiao L, Zheng H, Li J, Wang Q, et al. Neuroinflammation Mediated by NLRP3 Inflammasome After Intracerebral Hemorrhage and Potential Therapeutic Targets. Mol Neurobiol. 2020; 57(12): 5130-5149.

Li J, Xiao L, He D, et al. Mechanism of White Matter Injury and Promising Therapeutic Strategies of MSCs After Intracerebral Hemorrhage. Front Aging Neurosci. 2021; 13: 632054.

Ganesh Kumar N, Zuckerman SL, Khan IS, et al. Treatment of intracerebral hemorrhage: a selective review and future directions. J Neurosurg Sci. 2017; 61(5): 523-535.

Ramadhan MIA, Sitanaya SN, Hakim AHW, et al. The Role of Iron-Chelating Therapy in Improving Neurological Outcome in Patients with Intracerebral Hemorrhage: Evidence-Based Case Report. Medicina (Kaunas). 2023; 59(3): 453.

Hostettler IC, Seiffge DJ, Werring DJ. Intracerebral hemorrhage: an update on diagnosis and treatment. Expert Rev Neurother. 2019; 19(7): 679-694.

Reyes R, Viswanathan M, Aiyagari V. An update on neurocritical care for intracerebral hemorrhage. Expert Rev Neurother. 2019; 19(6): 557-578.

Sembill JA, Kuramatsu JB. Akutbehandlung der intrazerebralen Blutung [Acute treatment of intracerebral hemorrhage]. Med Klin Intensivmed Notfmed. 2019; 114(7): 613-619.